Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
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چکیده
منابع مشابه
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CD44 is the canonical receptor for hyaluronic acid (HA) but is capable of binding other ligands such as osteopontin (OPN) [1-3]. CD44-HA interactions are important mediators of the inflammatory response associated with immune cell development, differentiation, and recruitment [4]. In addition to the standard CD44 receptor (CD44s), CD44 can undergo alternative splicing to form CD44 variants (CD4...
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Lin28B, a Lin28 homologue, represses the biogenesis of let-7 microRNAs (miRNAs), has a role in tumorigenesis, and is considered a potential therapeutic target for various human malignancies. However, the associations between Lin28B and the clinical features and outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, we explored the clinical significance ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17150-3